adme agonist bioavailability bioequivalence biological half-life chemical kinetics competitive antagonist curve fitting digital object identifier dose-response relationship drug metabolism excretion formulation greek language initial volume of distribution inverse agonist liberation liquid chromatography-mass spectrometry loading dose mcsim mass spectrometry medication metabolism microdosing multi-compartment model nonmem neuropharmacology neuropsychopharmacology partial agonist patlak plot pharmacodynamics pharmacogenetics pharmacogenomics pharmacology physiological agonism and antagonism plasma protein binding psychopharmacology quadrupole mass analyzer rate of infusion receptor antagonist therapeutic index thermodynamics toxicity toxicokinetics volume of distribution